| Scarlett | 2020 | Tony | TV Movie |
| Schooled | 2019 | Mr. Mattis | TV Show |
| Brand New Old Love | 2018 | Bruce the 1st | Movie |
| Lodge 49 | 2018 | Bob Kruger | TV Show |
| Jeff & Some Aliens | 2017 | Zorby | TV Show |
| Billy Dilley's Super-Duper Subterranean Summer | 2017 | Big Doug | TV Show |
| The Late Bloomer | 2016 | Stagehand | Movie |
| Poor George | 2016 | Boss | Short Film |
| The Flight Before Christmas | 2015 | Noel Nichols | TV Movie |
| TripTank | 2014 | Caller, Charles, Coach Denim | TV Show |
| Last Week Tonight with John Oliver | 2014 | Newspaper Owner | TV Show |
| Christmas Under Wraps | 2014 | Frank Holliday | TV Movie |
| Live at the Foxes Den | 2013 | Earl Stein | Movie |
| Sirens | 2013 | Monsignor Sullivan | TV Show |
| Back in the Game | 2013 | Stinky Pete | TV Show |
| Spongebob Squarepants 4D Attraction: The Great Jelly Rescue | 2013 | Flying Dutchman (voice) | Short Film |
| Merkin Penal | 2013 | Buddha | Short Film |
| The Three Stooges | 2012 | Monsignor Ratliffe | Movie |
| Eye of the Hurricane | 2012 | Harvey Miken | Movie |
| Veep | 2012 | George Huntzinger | TV Show |
| Sullivan & Son | 2012 | Hank Murphy | TV Show |
| Motorcity | 2012 | Jacob | TV Show |
| 2 Broke Girls | 2011 | Blarney Bill | TV Show |
| Raising Hope | 2010 | Walt | TV Show |
| Passion Play | 2010 | Billy Berg | Movie |
| Adventure Time | 2010 | Prince Huge | TV Show |
| Kick Buttowski: Suburban Daredevil | 2010 | Clerk | TV Show |
| 17 Again | 2009 | Janitor | Movie |
| The Goode Family | 2009 | Charlie | TV Show |
| The Middle | 2009 | Mr. Ehlert | TV Show |
| Glenn Martin DDS | 2009 | Smitty | TV Show |
| The Marvelous Misadventures of Flapjack | 2008 | Captain K'nuckles, Captain Knuckles | TV Show |
| Childrens Hospital | 2008 | Dr. Santa Claus | TV Show |
| Fishmonger | 2008 | Captain K'Nuckles (voice, uncredited) | TV Show |
| I Flushy My Brushy | 2008 | Captain K'Nuckles (voice, uncredited) | TV Show |
| Starry Night | 2008 | Captain K'Nuckles (voice, uncredited) | TV Show |
| Sea Sick | 2008 | Captain K'Nuckles (voice, uncredited) | TV Show |
| Daddy Day Camp | 2007 | Uncle Morty | Movie |
| Love Comes Lately | 2007 | Boss | Movie |
| The Bill Engvall Show | 2007 | Ernest, Mr. Faulkner | TV Show |
| WordGirl | 2007 | Person #1, Police Officer | TV Show |
| Flagship | 2007 | Captain K'Nuckles (voice, uncredited) | TV Show |
| Psych | 2006 | Grandpa Spencer | TV Show |
| Mr. Vinegar and the Crossword | 2006 | Man | Short Film |
| Nearing Grace | 2005 | Clement C. Haydes | Movie |
| American Dad! | 2005 | Al | TV Show |
| It's Always Sunny in Philadelphia | 2005 | Captain Garcia | TV Show |
| My Gym Partner's a Monkey | 2005 | Coach Gills | TV Show |
| Supernatural | 2005 | Robert Singer | TV Show |
| The Buzz on Maggie | 2005 | Mr. Pesky | TV Show |
| The Thing with No Head | 2005 | Narrator (voice) | Short Film |
| Tom Goes to the Mayor | 2004 | Bernie Fusterillio | TV Show |
| I'm with Her | 2003 | Suds | TV Show |
| Lucky | 2003 | Jimmy the Deli Owner | TV Show |
| On the Spot | 2003 | | TV Show |
| Getting Hal | 2003 | Phil | Movie |
| A Gentleman's Game | 2002 | Tomato Face | Movie |
| Snow Dogs | 2002 | Ernie | Movie |
| Teamo Supremo | 2002 | Chief | TV Show |
| Sun Gods | 2002 | Plunkett | TV Show |
| Without Charlie | 2001 | Vicki's Father | Movie |
| Justice League | 2001 | Artie Bauman | TV Show |
| Lloyd in Space | 2001 | Grandpa Leo | TV Show |
| Bedazzled | 2000 | Priest | Movie |
| Drowning Mona | 2000 | Tow Truck Driver | Movie |
| Buzz Lightyear of Star Command | 2000 | Panchax | TV Show |
| Jackie Chan Adventures | 2000 | Giant Gnomekop, Gnomekop | TV Show |
| Pigs Next Door | 2000 | Jungle George | TV Show |
| Yes, Dear | 2000 | George Savitsky, Mr. Savitsky, Savitsky | TV Show |
| Kill the Man | 1999 | Grumpy Senior (as Brian Doyle Murray) | Movie |
| Stuart Little | 1999 | Cousin Edgar | Movie |
| Big Guy and Rusty the Boy Robot | 1999 | Po the Obliterator | TV Show |
| Family Guy | 1999 | Bidder #2, Luke, Salty | TV Show |
| Love & Money | 1999 | Finn McBride | TV Show |
| Rocket Power | 1999 | Kam Koerner | TV Show |
| SpongeBob SquarePants | 1999 | Atomic Dutchman, Dutchbomb, Flying Dutchman | TV Show |
| Doctor Dolittle | 1998 | Old Beagle (voice) | Movie |
| Legalese | 1998 | Roy's Father | TV Movie |
| CatDog | 1998 | Santa Claus | TV Show |
| The Hughleys | 1998 | Mr. Gifford | TV Show |
| As Good as It Gets | 1997 | Handyman | Movie |
| Between Brothers | 1997 | Stuart Franklin | TV Show |
| King of the Hill | 1997 | Jack | TV Show |
| Recess | 1997 | Larry Rogen, Tommy Tate | TV Show |
| Smart Guy | 1997 | Pete Gilroy | TV Show |
| The Angry Beavers | 1997 | Forest Animals, Smelly Jim | TV Show |
| Nightmare Ned | 1997 | Norm | TV Show |
| Big Business | 1997 | Johnny | Movie |
| Multiplicity | 1996 | Walt | Movie |
| Waiting for Guffman | 1996 | Red Savage | Movie |
| Pistol Pete | 1996 | Mayor | TV Show |
| Men Behaving Badly | 1996 | Bob Halverson | TV Show |
| Mr. Rhodes | 1996 | Buck Poloski | TV Show |
| The Daily Show | 1996 | President Grandpa | TV Show |
| Jury Duty | 1995 | Harry | Movie |
| My Brother's Keeper | 1995 | Curtis (as Brian Doyle Murray) | TV Movie |
| Life with Louie | 1995 | Pete | TV Show |
| Mr. Show with Bob and David | 1995 | Referee | TV Show |
| If Not for You | 1995 | Nestor | TV Show |
| Local Heroes | 1995 | Big Stosh | TV Show |
| The George Wendt Show | 1995 | Finnie | TV Show |
| Cabin Boy | 1994 | Skunk (as Brian-Doyle Murray) | Movie |
| Aaahh!!! Real Monsters | 1994 | Cop #3, Mulligan | TV Show |
| Duckman: Private Dick/Family Man | 1994 | Agnes Delrooney | TV Show |
| Ellen | 1994 | Burt Kovak | TV Show |
| Hey Arnold! | 1994 | Lasombra | TV Show |
| The George Carlin Show | 1994 | | TV Show |
| The Martin Short Show | 1994 | Gary | TV Show |
| Texan | 1994 | Sleazy Guy | TV Show |
| Groundhog Day | 1993 | Buster | Movie |
| Bakersfield P.D. | 1993 | Sergeant Bill Hampton | TV Show |
| Lois & Clark: The New Adventures of Superman | 1993 | Harlan Black | TV Show |
| Wayne's World | 1992 | Noah Vanderhoff | Movie |
| Frosty Returns | 1992 | Mr. Twitchell (voice) | TV Show |
| Love & War | 1992 | Fred the Bum | TV Show |
| JFK | 1991 | Jack Ruby | Movie |
| Nothing But Trouble | 1991 | Brian | Movie |
| Babe Ruth | 1991 | Marshall Hunt | TV Movie |
| Good Sports | 1991 | John 'Mac' MacKinney | TV Show |
| Get a Life | 1990 | Gus Borden, Ted Bains | TV Show |
| Wings | 1990 | Coach Snyder | TV Show |
| Small White House | 1990 | Johnny's Father | Movie |
| National Lampoon's Christmas Vacation | 1989 | Frank Shirley (as Brian Doyle Murray) | Movie |
| Ghostbusters II | 1989 | Psychiatrist (as Brian Doyle Murray) | Movie |
| How I Got Into College | 1989 | Coach Evans | Movie |
| The Experts | 1989 | Jones (as Brian Doyle Murray) | Movie |
| Seinfeld | 1989 | Mel Sanger | TV Show |
| Scrooged | 1988 | Earl Cross (as Brian Doyle Murray) | Movie |
| Superman 50th Anniversary | 1988 | Brian Connelly | TV Movie |
| Club Paradise | 1986 | Voit Zerbe | Movie |
| Legal Eagles | 1986 | Shaw | Movie |
| Married with Children | 1986 | Wayne | TV Show |
| Head Office | 1985 | Colonel Tolliver (as Brian Doyle Murray) | Movie |
| Sixteen Candles | 1984 | Reverend | Movie |
| The Razor's Edge | 1984 | Piedmont | Movie |
| National Lampoon's Vacation | 1983 | Kamp Komfort Clerk | Movie |
| Modern Problems | 1981 | Brian Stills | Movie |
| Caddyshack | 1980 | Lou Loomis | Movie |
| The Chevy Chase Show | 1977 | Various | TV Show |
| The TVTV Show | 1976 | Various | TV Movie |
| Shame of the Jungle | 1975 | Charles of the Pits #1 (English version, voice) | Movie |
| Saturday Night Live | 1975 | Patron, SNL Newsbreak Anchor, Various | TV Show |
| Saturday Night Live with Howard Cosell | 1975 | Various | TV Show |
| Fuzz | 1972 | Detective (as Brian Doyle Murray) | Movie |
| Sesame Street | 1969 | Man in Row Boat #2, Man in Rowboat #2 | TV Show |
